05) within 7 days of convalescent plasma transfusion. Of the 10 patients, 9 patients had full recovery and 1 patient died.
Convalescent plasma therapy is highly safe and clinically feasible and reduces mortality in kidney transplant recipients with severe COVID-19. Larger clinical registries and randomized clinical trials should be conducted to further explore the clinical outcomes associated with convalescent plasma use in kidney transplant recipients with severe COVID-19.
Convalescent plasma therapy is highly safe and clinically feasible and reduces mortality in kidney transplant recipients with severe COVID-19. Larger clinical registries and randomized clinical trials should be conducted to further explore the clinical outcomes associated with convalescent plasma use in kidney transplant recipients with severe COVID-19.The right kidney is not commonly selected for donor nephrectomy compared with the left kidney. Most left donor nephrectomies are performed by laparoscopic approach, whereas open donor nephrectomies are preferred on the right side. We present our experience of right laparoscopic donor nephrectomy, which was a substantial percentage of all performed laparoscopic donor nephrectomies.
We retrospectively analyzed all the donor nephrectomies performed at a single center, including indicators for right side open donor nephrectomy, as well as the demographic details of donors and intraoperative events, complications, and hospital stay for right side laparoscopic donor nephrectomy. https://www.selleckchem.com/products/phosphoenolpyruvic-acid-monopotassium-salt.html Recipients were evaluated for outcome and complications.
We performed 850 donor nephrectomies, including 640 left donor nephrectomies and 210 right donor nephrectomies. Of 210 right donor nephrectomies, 160 cases were performed laparoscopically, and 50 cases were open surgeries. Common indications for choice of right open donor nephretomy or right side open donor nephrectomy. Careful consideration of recipient factors is very important along with donor factors before opting for an open or laparoscopic approach on the right side. Slight modifications in technique may provide a few additional millimeters of length, which can significantly increase the incentive to choose laparoscopic donor nephrectomy on the right side.Kidney transplant is the treatment of choice for end-stage renal disease. Because of the insufficient supply of donor organs for transplant, the number of patients on the transplant wait list is increasing. We analyzed demographic and clinical factors including sensitization status of patients on the kidney transplant wait list in our center.
Patients on the kidney transplant wait list at Ankara University School of Medicine by July 2018 were evaluated. Data on demographics, comorbidities, treatment characteristics, and immunologic properties were collected.
The study included 528 kidney transplant candidates whose mean time on the deceased donor organ wait list was 57 ± 47 months. Enlisted patients were aged 53 ± 13 years, and 95% of them were on dialysis. Dialysis vintage was longer and percentage of patients who had anti-HLA antibodies was higher in women than men (P = .004 and P &lt; .001, respectively). Levels for median fluorescence intensity were higher in women compared with men (class I, P &lt; donor organ pool and donation rates are needed to increase the rate of deceased donor kidney transplant in Turkey.Despite data showing equivalent outcomes between grafts from marginal versus standard criteria deceased liver donors, elevated donor transaminases constitute a frequent reason to decline potential livers. We assessed the effect of donor transaminase levels and other characteristics on graft survival.
We performed a retrospective cohort analysis of adult first deceased donor liver transplant recipients with available transaminase levels registered in the Organ Procurement and Transplantation Network database (2008-2018). We used Cox proportional hazards regression to determine the effects of donor characteristics on graft survival.
Of 53?913 liver transplants, 52?158 were allografts from donors with low transaminases (? 500 U/L; group A) and 1755 were from donors with elevated transaminases (&gt; 500 U/L; group B). Group A recipients were more likely to be hospitalized (P = .01) or in intensive care (P &lt; .001) or to have mechanical assistance (P &lt; .001), portal vein thrombosis (P = .01), diabetes mellitus (P = .003), or dialysis the week before liver transplant (P = .004). Multivariable analysis (controlling for recipient characteristics) showed donor risk factors of graft failure included diabetes mellitus (P &lt; .001), donation after cardiac death (P &lt; .001), total bilirubin &gt; 3.5 mg/dL (P &lt; .001), serum creatinine &gt; 1.5 mg/dL (P = .01), and cold ischemia time &gt; 6 hours (P &lt; .001). Regional organ sharing showed lower risk of graft failure (P = .02). Donor transaminases &gt; 500 U/L were not associated with graft failure (relative risk, 1.02; 95% CI, 0.91-1.14; P = .74).
Donor transaminases &gt; 500 U/L should not preclude the use of liver grafts. Instead, donor total bilirubin &gt; 3.5 mg/dL and serum creatinine &gt; 1.5 mg/dL appear to be associated with higher likelihood of graft failure after liver transplant.1.5 mg/dL appear to be associated with higher likelihood of graft failure after liver transplant.This case report describes the first ex situ full-right/full-left splitting of a liver from a pediatric deceased donor in the Middle East with an excellent outcome for both recipients. The left lateral split-liver transplant requires division of the deceased donor liver into a left lateral lobe for a pediatric recipient and an extended right lobe for an adult recipient, thus producing only 1 graft for a pediatric recipient. Full-right/full-left liver transplant, which splits the liver along the line of Cantlie, is a much more complex and challenging surgery, even though the technique is fully developed, and is theoretically able to produce 2 sizeable grafts for 2 pediatric recipients. However, the full-right/full-left liver transplant remains limited because of the small vascular structures and therefore was not recommended and was not previously described in the literature.